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Clin. Vaccine Immunol. doi:10.1128/CVI.00471-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Major outer membrane proteins from many species of Campylobacter cross-react with cholera toxin

Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait, and Australian Bacterial Pathogenesis Program, and ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Victoria 3800, Australia

^* To whom correspondence should be addressed. Email: john{at}hsc.edu.kw.

	Abstract

We have previously shown that Campylobacter jejuni strains do not produce a functional cholera toxin-like toxin (CTLT) detectable in Chinese hamster ovary (CHO) cell assay. Instead, the 53-kDa molecular weight, major outer membrane protein (OMP), PorA of C. jejuni reacted with cholera toxin (CT) antibody in immunoblot. We extend this observation to other species of Campylobacter including C. coli, C. lari, C. fetus, C. hyointestinalis and C. upsaliensis, in which the common 53-kDa OMP reacted with CT antibody by immunoblot. There were additional reactive bands in C. fetus. As with C. jejuni, this would lead to the erroneous conclusion that these additional species also produce a functional CTLT. However, this common cross-reactive OMP can be explored as a vaccine candidate to prevent campylobacteriosis.