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Clin. Vaccine Immunol. doi:10.1128/CVI.00453-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Improved Performance of Enzyme-Linked Immunosorbent Assays and the Effect of HIV Co-Infection on the Serologic Detection of Herpes Simplex Virus Type-2 in Rakai, Uganda

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Department of Laboratory Medicine, University of Washington, Seattle, Washington; Institute of Public Health, Makerere University, Kampala, Uganda; Department of Population, Family and Reproductive Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD

^* To whom correspondence should be addressed. Email: tquinn{at}jhmi.edu.

	Abstract

820 Ugandan subjects were tested by Focus HerpeSelect ELISA, Kalon HSV-2 ELISA, and BioKit rapid test, and compared to Western blot. Higher than standard index cutoff values gave optimal sensitivity and specificity. Kalon ELISA was the optimal assay when an index value of 1.5 was used (sensitivity 91.7%, specificity 92.4%).