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CVI Accepts, published online ahead of print on 12 December 2007
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Clin. Vaccine Immunol. doi:10.1128/CVI.00414-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Performance Characteristics of IgM anti-HBc Measurement by Microparticle Enzyme and Chemilluminescence Immunoassays in Sera of Patients with HbeAg-Negative Chronic Hepatitis B Virus Infection

Emilia Hadziyannis*, Emanuel Manesis, Dimitrios Vassilopoulos, Anastasia Georgiou, and Athanasios Archimandritis

Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece, 114 Vas Sophias Ave, Athens 11527, Greece

* To whom correspondence should be addressed. Email: emhadzi{at}med.uoa.gr.


  Abstract

IMx, AxSYM and Architect IgM anti-HBc assays, in HBeAg negative chronic HBV infection, were compared. Despite good intra- and inter-assay CVs, significantly different values and low correlation (AxSYM overestimation and Architect underestimation) were observed. Association and cut-off values for distinguishing patients with viral replication should be established for all methods.




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Copyright © 2007 by the American Society for Microbiology. All rights reserved.