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CVI Accepts, published online ahead of print on 12 December 2007
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CVI.00383-07v1
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Clin. Vaccine Immunol. doi:10.1128/CVI.00383-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Cryptococcal Glucoxylomannan does not Exhibit Cross-Reactivity in the MVistaTM Histoplasma antigen enzyme immunoassay (EIA)

David Zhuang, Chadi Hage, Magdia De Jesus, Emily Hackett, Michelle Durkin, Thomas E. Davis, Arturo Casadevall, and L. Joseph Wheat*

MiraVista Diagnostics, Indianapolis, IN, USA; Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans' Administration Hospital, 1481 West Tenth Street, Indianapolis, IN 46202; Albert Einstein College of Medicine, 1300 Morris Park Avenue, Forchheimer 411, Bronx, NY 10461; Indiana University School of Medicine, Department of Pathology, Wishard Memorial Hospital, 1001 West Tenth Street, Indianapolis, IN 46202

* To whom correspondence should be addressed. Email: jwheat{at}miravistalabs.com.


  Abstract

The potential for cross reaction between Cryptococcus neoformans and Histoplasma capsulatum in antigen assays was evaluated. We tested patient samples, spleen from infected mice, and purified polysaccharides in the MVistaTM Histoplasma antigen enzyme immunoassay and Cryptococcal Antigen Latex Agglutination System for cross reactivity, and none was observed.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.