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Clin. Vaccine Immunol. doi:10.1128/CVI.00364-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

COMPARISON OF TWO COMMERCIALLY AVAILABLE INTERFERON-GAMMA BLOOD TESTS FOR IMMUNODIAGNOSIS OF TUBERCULOSIS INFECTION

Servei de Microbiologia. Servei de Pneumologia. Hospital Universitari "Germans Trias i Pujol", Fundació Institut en Ciències de la Salut "Germans Trias i Pujol". Badalona. Spain, Universitat Autònoma de Barcelona. Bellaterra. Spain, Ciber Enfermedades Respiratorias. Instituto de Salud Carlos III. Spain, Unidad de Prevención y Control de la Tuberculosis de Barcelona. Spain

^* To whom correspondence should be addressed. Email: jadominguez.igtp.germanstrias{at}gencat.net.

	Abstract

We have evaluated T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma-interferon tests are unaffected by the prior BCG-vaccination. Among children not BCG-vaccinated with a positive tuberculin skin test, QFN-G-IT was negative in the 60.4%, and T-SPOT.TB in the 56.6% of cases.

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