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CVI Accepts, published online ahead of print on 16 January 2008
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CVI.00359-07v1
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Clin. Vaccine Immunol. doi:10.1128/CVI.00359-07
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Recognition of Mycobacterium tuberculosis MPT-51 and GlcB by the humoral immune response of Brazilian TB Patients

Cristina de Melo Cardoso Almeida, Arioldo C. Vasconcelos Júnior, André Kipnis, Ana Lúcia S. Sgambatti de Andrade, and Ana Paula Junqueira Kipnis*

Departamento de Microbiologia, Imunologia, Parasitologia e Patologia, Laboratório de Imunopatologia das Doenças Infecciosas, Laboratório de Bacteriologia Molecular, Departamento de Saúde Coletiva, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia-Go, Brasil

* To whom correspondence should be addressed. Email: anapaula{at}iptsp.ufg.br.


  Abstract

Humoral response to recombinant MPT-51 and GlcB was determined using ELISA. IgM against MPT-51 and IgG against GlcB were higher among TB patients than controls individuals. Combining MPT-51 and GlcB assays, a 90.8% specificity and 75.5% sensitivity was observed. MPT-51 and GlcB were recognized by the humoral response of Brazilian TB patients.




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Copyright © 2008 by the American Society for Microbiology. All rights reserved.