Induction of antitumor-acquired immunity by baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mice

Department of Life and Environmental Sciences, and High Technology Research Center, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan, Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba 260-8670, Japan

^* To whom correspondence should be addressed. Email: hiroshi.takaku{at}it-chiba.ac.jp.

	Abstract

The baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been studied as a gene therapy vector. Here, We demonstrated that AcMNPV induces antitumor-acquired immunity. These results suggest that AcMNPV has the potential to be an efficient virus or tumor therapy agent which induces innate and acquired immunity.