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CVI Accepts, published online ahead of print on 5 December 2007
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CVI.00265-07v1
15/2/388    most recent
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Clin. Vaccine Immunol. doi:10.1128/CVI.00265-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Evaluation of the Ultrasensitive Human Immunodeficiency Virus (HIV) -1 p24 Antigen Assay on Dried Blood Spots (DBS) for Infant Diagnosis

Janet C Patton, Ashraf H Coovadia, Tammy M Meyers, and Gayle G Sherman*

Wits Pediatric HIV Clinics, Wits Health Consortium; Departments of Molecular Medicine and Hematology and Pediatrics, University of the Witwatersrand, Johannesburg, South Africa.; National Health Laboratory Service, South Africa

* To whom correspondence should be addressed. Email: gayle.sherman{at}nhls.ac.za.


  Abstract

The diagnostic accuracy of the modified p24 Ag assay on pediatric dried blood spots was evaluated. Samples analyzed within 6 weeks of collection yielded no false positive results (specificity 100%) and few false negative results (sensitivity 96.5%–98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis.




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Copyright © 2007 by the American Society for Microbiology. All rights reserved.