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Clinical and Diagnostic Laboratory Immunology, March 1998, p. 251-253, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Dehydroepiandrosterone Sulfate Treatment of Mice Modulates Infection with Schistosoma mansoni

Padraic G. Fallon,* Emma J. Richardson, Frances M. Jones, and David W. Dunne

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom

Received 18 September 1997/Returned for modification 7 November 1997/Accepted 11 December 1997

Female mice treated with dehydroepiandrosterone sulfate early during infection were partially protected (P < 0.05-0.005) from Schistosoma mansoni infection. Hormone treatment did not modify parasite-specific cellular or humoral responses. Serum dehydroepiandrosterone sulfate levels and testosterone infection were negatively correlated, r = -0.621 and r = -0.653, respectively, with schistosome worm burden. The partial resistance to schistosome infection in dehydroepiandrosterone sulfate-treated female mice may be due to the known antischistosomular activity of testosterone.

* Corresponding author. Mailing address: Department of Pathology, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QP, United Kingdom. Phone: 44 1233 333339. Fax: 44 1233 333741. E-mail: pgf{at}mole.bio.cam.ac.uk.

Clinical and Diagnostic Laboratory Immunology, March 1998, p. 251-253, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
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Copyright © 1998 by the American Society for Microbiology. All rights reserved.