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Clinical and Vaccine Immunology, June 2009, p. 949-952, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00442-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Antibodies to Staphylococcus aureus Bone Sialoprotein-Binding Protein Indicate Infectious Osteomyelitis{triangledown}

Lena Persson,1,2 Christian Johansson,1,# and Cecilia Rydén1,2*

Department of Medical Biochemistry and Microbiology, Uppsala University BMC, Box 582, SE-75123 Uppsala, Sweden,1 Department of Infectious Diseases, Uppsala Academic Hospital, SE-75185 Uppsala, Sweden2

Received 13 November 2008/ Returned for modification 22 December 2008/ Accepted 6 April 2009

Discrimination of soft tissue infection from osteomyelitis in diabetic foot infections is a common clinical problem. Staphylococcus aureus isolates from patients with osteomyelitis express bone sialoprotein-binding protein (Bbp) that binds the bone matrix protein bone sialoprotein. The serological assay with Bbp discriminated cases of osteomyelitis from soft tissue infections in patients with diabetic foot ulcers.

* Corresponding author. Mailing address: Departments of Medical Biochemistry and Microbiology/Medical Sciences, Uppsala University BMC, Box 582, S-751 23 Uppsala, Sweden. Phone: 46-18-471 4234. Fax: 46-18-471 4673. E-mail: Cecilia.Ryden{at}imbim.uu.se

{triangledown} Published ahead of print on 15 April 2009.

# Present address: Department of Neurology, Södersjukhuset, Stockholm, Sweden.

Clinical and Vaccine Immunology, June 2009, p. 949-952, Vol. 16, No. 6
1071-412X/09/$08.00+0     doi:10.1128/CVI.00442-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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