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Clinical and Diagnostic Laboratory Immunology, May 2005, p. 680-682, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.680-682.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Strongyloides Hyperinfection and Hypogammaglobulinemia

Raymond C. S. Seet,1* Lee Gong Lau,2 and Paul Ananth Tambyah1

Department of Medicine,1 Department of Hematology-Oncology, National University Hospital, Singapore2

Received 6 January 2005/ Returned for modification 15 February 2005/ Accepted 23 February 2005

We report strongyloides hyperinfection in two patients with generalized hypogammaglobulinemia from multiple myeloma and nephrotic syndrome, despite a significant strongyloides-specific immunoglobulin G (IgG) response. In contrast to reports on animals, where human IgG was shown to be a protective antibody, our observation suggests that in humans, immunity to the infective-stage larvae is not protective against the autoinfective larvae, which are the causative agents of strongyloides hyperinfection.

* Corresponding author. Mailing address: Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074. Phone: 65-67792516. Fax: 65-67794112. E-mail: raymond_seet{at}nus.edu.sg.

Clinical and Diagnostic Laboratory Immunology, May 2005, p. 680-682, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.680-682.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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