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Clinical and Diagnostic Laboratory Immunology, May 2005, p. 677-679, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.677-679.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Multiple Autoantigen Mimotopes of Infectious Agents Induce Autoimmune Arthritis and Uveitis in Lewis Rats

Gerhild Wildner* and Maria Diedrichs-Moehring

Section of Immunobiology, Dept. of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany

Received 5 November 2004/ Returned for modification 11 January 2005/ Accepted 2 March 2005

We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other "self" or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.

* Corresponding author. Mailing address: Section of Immunobiology, Dept. of Ophthalmology, Ludwig-Maximilians-University, Mathildenstr. 8, 80336 Munich, Germany. Phone: 49 89 5160 3888. Fax: 49 89 5160 3045. E-mail: Gerhild.Wildner{at}med.uni-muenchen.de.

Clinical and Diagnostic Laboratory Immunology, May 2005, p. 677-679, Vol. 12, No. 5
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.5.677-679.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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Copyright © 2005 by the American Society for Microbiology. All rights reserved.