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CVI Accepts, published online ahead of print on 30 April 2008
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Clin. Vaccine Immunol. doi:10.1128/CVI.00088-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Development and characterization of an equine infectious anemia virus Env pseudotyped reporter virus

R. L. Tallmadge, M. A. Brindley, J. Salmans, R. H. Mealey, W. Maury, and S. Carpenter*

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA; Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA

* To whom correspondence should be addressed. Email: scarp{at}vetmed.wsu.edu.


  Abstract

We developed a replication-defective reporter virus pseudotyped with the envelope glycoprotein of equine infectious anemia virus (EIAV). The in vitro host range and neutralization phenotype of EIAV-Env pseudotyped virus were similar to replication-competent virus. An EIAV-Env pseudovirus will improve antigenic characterization of viral variants and evaluation of lentivirus vaccines.




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Copyright © 2008 by the American Society for Microbiology. All rights reserved.