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CVI Accepts, published online ahead of print on 9 April 2008
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Clin. Vaccine Immunol. doi:10.1128/CVI.00026-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Pulmonary Tuberculosis: Enhancement of Diagnostic Efficiency by Associating Microbiological Methods and the Immunological QuantiFERON®-TB Gold Assay

Kelly Aparecida Kanunfre, Olavo Henrique Munhoz Leite, Max Igor Lopes, Marcelo Litvoc, and Antonio Walter Ferreira*

Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil; Clinic for Infectious Diseases of the Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil; Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil

* To whom correspondence should be addressed. Email: clawsmbf{at}usp.br.


  Abstract

This study was designed to examine the use of QuantiFERON®-TB Gold as an aid in the diagnosis of active pulmonary tuberculosis in Brazilian patients. Using the ROC curve, the cutoff was adjusted to ≥ 0.20 UI/ml. The sensitivity increased to 86% with 100% specificity. All TB patients with sputum smear microscopy and negative culture were positive using the test.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.