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CVI Accepts, published online ahead of print on 16 April 2008
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CVI.00009-08v1
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Clin. Vaccine Immunol. doi:10.1128/CVI.00009-08
Copyright (c) 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Evaluation of IgG antibody avidity in Mexican infants after primary immunization with 3 doses of PRP-T Haemophilus influenzae type b vaccine

Patricia Gómez-de-León*, F. Javier Díaz-García, Alberto Villaseñor-Sierra, Jorge Segura, Martha I. Carranza, José Luis Arredondo G., and José Ignacio Santos

Departamento de Salud Pública, Facultad de Medicina. Universidad Nacional Autónoma de México. Mexico, D.F., Mexico; Laboratorio de Microbiología Molecular, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México; Dirección de Investigación Clínica; Instituto Nacional de Pediatría. Secretaría de Salud. Mexico, D. F., Mexico; Hospital Infantil de México, Federico Gómez. Secretaría de Salud. Mexico, D. F., Mexico; Departamento de Medicina Experimental, Facultad de Medicina. Universidad Nacional Autónoma de México. Mexico, D. F., Mexico

* To whom correspondence should be addressed. Email: pglc{at}servidor.unam.mx.


  Abstract

Serum IgG concentrations and avidities specific to Haemophilus influenzae type b were measured in 208 children living in Guadalajara and Mexico City. Protective concentrations where found in 98.9% and 100.0% of participants, respectively. GMCs differed between both populations and/or age groups. Mean avidities differed only among the 7-12 month-old children. DTwP-HB/Hib primary vaccination seems to induce protection in Mexican children.




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Copyright © 2008 by the American Society for Microbiology. All rights reserved.