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Clinical and Diagnostic Laboratory Immunology, November 2002, p. 1382-1384, Vol. 9, No. 6
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.6.1382-1384.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Differential Immune Response to the Variable Surface Loop Antigen of P66 of Borrelia burgdorferi Sensu Lato Species in Geographically Diverse Populations of Lyme Borreliosis Patients

Katharina Ornstein,1 Yngve Östberg,2 Jonas Bunikis,3 Laila Noppa,2 Johan Berglund,1 Ragnar Norrby,4 and Sven Bergström2*

Department of Medical Microbiology, Dermatology, and Infection, Lund University, Lund,1 Department of Molecular Biology, Umeå University, Umeå,2 Swedish Institute for Infectious Disease Control, Stockholm, Sweden,4 Departments of Microbiology, Molecular Genetics, and Medicine, University of California Irvine, Irvine, California3

Received 7 November 2001/ Returned for modification 25 April 2002/ Accepted 26 August 2002

We have studied the immune response to a variable surface-exposed loop region of the P66 outer membrane protein from Borrelia burgdorferi sensu lato by using an enzyme immunoassay. Lyme borreliosis populations found in North America and Sweden were preferentially more seroreactive to P66 from their respective regional species, namely, B. burgdorferi sensu stricto and B. garinii and B. afzelii, respectively.

* Corresponding author. Mailing address: Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden. Phone: 46 90 7856726. Fax: 46 90 772630. E-mail: sven.bergstrom{at}molbiol.umu.se.

Clinical and Diagnostic Laboratory Immunology, November 2002, p. 1382-1384, Vol. 9, No. 6
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.6.1382-1384.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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