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Clinical and Diagnostic Laboratory Immunology, May 2002, p. 731-735, Vol. 9, No. 3
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.3.731-735.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Activated T Lymphocytes Disappear from Circulation during Endotoxemia in Humans

K. S. Krabbe, H. Bruunsgaard, J. Qvist, L. Fonsmark, K. Møller, C. M. Hansen, P. Skinhøj, and B. K. Pedersen*

Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Received 25 June 2001/ Returned for modification 7 November 2001/ Accepted 22 January 2002

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA+ CD45RO-) that were less likely to undergo apoptosis (CD28+), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA- CD45RO+) as well as a phenotype linked to apoptosis (CD95+ CD28-). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.

* Correspondending author. Mailing address: Department of Infectious Diseases M7641, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. Phone: (45) 3545 7797. Fax: (45) 3545 6648. E-mail: bkp{at}rh.dk.

Clinical and Diagnostic Laboratory Immunology, May 2002, p. 731-735, Vol. 9, No. 3
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.3.731-735.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.



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Copyright © 2002 by the American Society for Microbiology. All rights reserved.