This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kemp, K. Articles by Hviid, L. Search for Related Content PubMed PubMed Citation Articles by Kemp, K. Articles by Hviid, L.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, May 2002, p. 720-722, Vol. 9, No. 3
1071-412X/02/$04.00+0     DOI: 10.1128/CDLI.9.3.720-722.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Increased Levels of Soluble CD30 in Plasma of Patients with Plasmodium falciparum Malaria

Center for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark,¹ Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon,² Department of Child Health, Korle-Bu Teaching Hospital, University of Ghana Medical School, Accra, Ghana,³ Unité d'Immunologie Moléculaire des Parasites, CNRS URA 1960, Institut Pastéur, Paris, France⁴

Received 19 June 2001/ Returned for modification 22 October 2001/ Accepted 22 January 2002

Levels of soluble CD30 (sCD30) in serum were elevated in patients with Plasmodium falciparum malaria but showed decline following treatment. The levels of sCD30 in serum were correlated significantly with the expression of gamma interferon by peripheral T cells. These data suggest that CD30⁺ cells are upregulated during a malaria attack and that they may play a regulating role at the site of inflammation.