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Diagnosis of Helicobacter pylori Infection in Children: Comparison of a Salivary Immunoglobulin G Antibody Test with the [¹³C]Urea Breath Test

Department of Epidemiology, University of Ulm, Ulm,¹ Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany,³ Enteric Products, Inc., Stony Brook, New York²

Received 10 September 2001/ Returned for modification 11 October 2001/ Accepted 20 November 2001

The prevalence of Helicobacter pylori infection in a population-based sample of 477 children (mean age ± standard deviation, 5.8 ± 0.5 years) determined by the [¹³C]urea breath test ([¹³C]UBT) was 10.7% (95% confidence interval [CI], 8.1 to 13.8%), and that determined by salivary enzyme-linked immunosorbent assay (ELISA) was 11.9% (95% CI, 9.2 to 15.2%). Compared to the [¹³C]UBT, the sensitivity and specificity of the salivary ELISA were 80.9% (95% CI, 66.3 to 90.4%) and 95.3% (95% CI, 92.7 to 97.1%), respectively.

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