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Clinical and Diagnostic Laboratory Immunology, January 2002, p. 194-197, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.194-197.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Influence of Host Factors on Immunoglobulin G Concentration in Oral Fluid Specimens

Timothy C. Granade,1* Susan K. Phillips,1 Wendy Kitson-Piggott,2 Perry Gomez,3 Bisram Mahabir,4 Herbert Oleander,3 J. Richard George,1,{dagger} James Baggs,1,{ddagger} and Bharat Parekh1

Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Caribbean Epidemiology Centre,2 Ministry of Health and Environment, Nassau, Bahamas,3 Ministry of Health, Trinidad and Tobago, Port-of-Spain, Trinidad, British West Indies4

Received 31 July 2001/ Returned for modification 5 September 2001/ Accepted 22 October 2001

The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 µg/ml, P = 0.0001), sex (female, +1.23 µg/ml, P = 0.004), dentition (+2.83 µg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 µg/ml, P = 0.0001), and time since the last meal (+3.55 µg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.

* Corresponding author. Mailing address: Centers for Disease Control and Prevention, 1600 Clifton Rd. D-12, Atlanta, GA 30333. Phone: (404) 639-3850. Fax: (404) 639-2660. E-mail: TGranade{at}cdc.gov.

{dagger} Present address: Orasure Technologies, Beaverton, Oreg.

{ddagger} Present address: Washington Department of Labor and Industries, Olympia, Wash.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 194-197, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.194-197.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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