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Clinical and Diagnostic Laboratory Immunology, January 2002, p. 101-104, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.101-104.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.

Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis

Maria L. B. Sousa-Atta,1 Gregório S. Salamé,2 Argemiro D’Oliveira, Jr,3 Roque P. Almeida,3 Ajax M. Atta,1 and Edgar M. Carvalho3*

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia da Universidade Federal da Bahia,1 Núcleo de Medicina Tropical, Universidade de Brasília,2 Serviço de Imunologia do Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, 40110-160 Salvador, Bahia, Brazil3

Received 15 May 2001/ Returned for modification 7 August 2001/ Accepted 24 October 2001

High levels of antileishmanial immunoglobulin E (IgE) antibodies are associated with disease activity in visceral leishmaniasis. Herein, we report our observations about the relationship between antileishmanial IgE antibodies and clinical aspects of cutaneous leishmaniasis. This study was carried out with 45 patients (29 male and 16 female), with ages ranging from 11 to 48 years. All subjects were from an area to which leishmaniasis is endemic, Corte de Pedra (Bahia, Brazil), and the duration of the illness was <=30 days. The patients were classified as positive or negative for IgE serology in enzyme-linked immunosorbent assay with leishmanial antigens. IgE antibodies were detected in 18 patients (optical density, 0.421 ± 0.30; 95% confidence interval, 0.27 to 0.57), and only 3 (17%) had more than one ulcer. In this group the diameter of Montenegro’s reaction was 18 ± 12.2 mm. In the group with negative IgE serology, 11 of 27 patients (48%) presented two or more cutaneous ulcers, and the mean of the skin test result was 9 ± 6.9 mm. There was a positive correlation between IgE antibody levels and Montenegro’s reaction size and an inverse correlation between IgE antileishmanial antibodies and the number of skin ulcers. The presence of antileishmanial IgE antibodies in cutaneous leishmaniasis may be a result of immunoregulatory events with clinical implications.

* Corresponding author. Mailing address: Hospital Universitário Professor Edgar Santos, Serviço de Imunologia, 5° andar, Rua João das Botas, s/n Canela, 40110-160 Salvador, Bahia, Brazil. Phone: (55) (71)2377353. Fax: (55) (71)2457110. E-mail: edgar{at}ufba.br.

Clinical and Diagnostic Laboratory Immunology, January 2002, p. 101-104, Vol. 9, No. 1
1071-412X/01/$04.00+0     DOI: 10.1128/CDLI.9.1.101-104.2002
Copyright © 2002, American Society for Microbiology. All Rights Reserved.





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