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Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1036-1038, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1036-1038.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

High Serum Interleukin-10 and Tumor Necrosis Factor Alpha Levels in Chronic Paracoccidioidomycosis

M. C. Fornari,1 A. J. Bava,1 M. T. Guereño,1 V. E. Berardi,1 M. R. Silaf,2 R. Negroni,3 and R. A. Diez1,*

Laboratorio de Inmunofarmacologia, Facultad de Medicina, UBA,1 Academia Nacional de Medicina,2 and Hospital Muñiz,3 Buenos Aires, Argentina

Received 18 January 2001/Returned for modification 22 February 2001/Accepted 7 June 2001

In patients with chronic paracoccidioidomycosis (n = 10), levels of tumor necrosis factor alpha, interleukin-10, and interleukin-2 in serum, measured by enzyme-linked immunosorbent assay (in picograms per milliliter, as mean ± standard error of the mean), were higher than in normal controls (n = 8): 186 ± 40 versus 40 ± 7 (P < 0.05), 203 ± 95 versus 20 ± 8 (P = 0.001), and 96.3 ± 78.57 versus 1.19 ± 1.19 (P = 0.045), respectively. Gamma interferon and interleukin-4 levels were similar in patients and controls.


* Corresponding author. Mailing address: Immunopharmacology Lab, Department of Pharmacology, School of Medicine (UBA), Paraguay 2155, Piso 16, 1121 Buenos Aires, Argentina. Phone and fax: (5411) 4964-0505. E-mail: rdiez{at}fmed.uba.ar.


Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1036-1038, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1036-1038.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.






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Copyright © 2001 by the American Society for Microbiology. All rights reserved.