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Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1028-1030, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1028-1030.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Significant Role of Interleukin-8 in Pathogenesis of Pulmonary Disease Due to Mycoplasma pneumoniae Infection

Mitsuo Narita,1,* Hiroshi Tanaka,2 Satoshi Yamada,3 Shosaku Abe,2 Tadashi Ariga,4 and Yukio Sakiyama4

Department of Pediatrics, Sapporo Tetsudo (JR) Hospital, Chuo-ku, Sapporo 060-0033,1 Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556,2 Department of Pediatrics, Health Sciences University of Hokkaido, Kita-ku, Sapporo 002-8072,3 and Department of Gene Therapy, Hokkaido University School of Medicine, Kita-ku, Sapporo 060-8638,4 Japan

Received 26 March 2001/Returned for modification 23 May 2001/Accepted 18 June 2001

We found elevated levels of interleukin-8 in pleural fluid samples from patients with pleural effusion and with a sustained fibrotic change of the lung due to Mycoplasma pneumoniae infection. This result suggests a critical role of interleukin-8 in the pathogenesis of a certain type of pulmonary disease caused by M. pneumoniae.

* Corresponding author. Mailing address: Department of Pediatrics, Sapporo Tetsudo (JR) Hospital, N 3 E 1 Chuo-ku, Sapporo 060-0033, Japan. Phone: 81-11-241-4971. Fax: 81-11-222-9260. E-mail: naritamy{at}d5.dion.ne.jp.

Clinical and Diagnostic Laboratory Immunology, September 2001, p. 1028-1030, Vol. 8, No. 5
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.5.1028-1030.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.