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*Shingles

Clinical and Diagnostic Laboratory Immunology, July 2001, p. 850-851, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.850-851.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Spinal Cord Involvement in Uncomplicated Herpes Zoster

Israel Steiner,1,* Bettina Steiner-Birmanns,1 Netta Levin,1 Klila Hershko,2 Isabelle Korn-Lubetzki,3 and Iftah Biran1

Departments of Neurology1 and Dermatology,2 Hadassah University Hospital, and The Neurological Service, Bikur Cholim Hospital,3 Jerusalem, Israel

Received 28 March 2001/Accepted 9 May 2001

We prospectively evaluated herpes zoster patients during the acute phase of the disease for central nervous system involvement. Of 24 patients with spinal zoster, 13 (54%) had spinal cord abnormality, which was asymptomatic in 12 of the 13. Age but not lack of acyclovir treatment was associated with such involvement. In all but 2, neurological involvement resolved within 6 months. Although the mechanism responsible for the neurological abnormalities is unknown, findings may support the hypothesis that zoster is associated with spread of viral infection into the spinal cord and therefore support the possibility that zoster is due to active viral replication in the ganglion.

* Corresponding author. Mailing address: Laboratory of Neurovirology, Department of Neurology, Hadassah University Hospital, P.O. Box 12000, Jerusalem, 91120, Israel. Phone: 972/2/6776952. Fax: 972/2/6437782. E-mail: isteiner{at}md2.huji.ac.il.

Clinical and Diagnostic Laboratory Immunology, July 2001, p. 850-851, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.850-851.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.




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Copyright © 2001 by the American Society for Microbiology. All rights reserved.