CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Strate, B. W. A.
Right arrow Articles by Hamprecht, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Strate, B. W. A.
Right arrow Articles by Hamprecht, K.

Clinical and Diagnostic Laboratory Immunology, July 2001, p. 818-821, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.818-821.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Viral Load in Breast Milk Correlates with Transmission of Human Cytomegalovirus to Preterm Neonates, but Lactoferrin Concentrations Do Not

B. W. A. van der Strate,1,* M. C. Harmsen,2,3 P. Schäfer,4 P. J. Swart,1,dagger T. H. The,2 G. Jahn,5 C. P. Speer,6 D. K. F. Meijer,1 and K. Hamprecht5

Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Groningen University Institute for Drug Exploration, 9713 AV Groningen,1 and Department of Clinical Immunology2 and Department of Pathology/Laboratory Medicine,3 Groningen University Institute for Drug Exploration, University Hospital Groningen, 9713 GZ Groningen, The Netherlands, and Institut für Medizinische Mikrobiologie and Immunologie, Universitäts-Krankenhaus Eppendorf, D-20246 Hamburg,4 Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, D-72076 Tübingen,5 and Children's Hospital, University of Würzburg, 97080 Würzburg,6 Germany

Received 27 December 2000/Returned for modification 7 February 2001/Accepted 11 April 2001

In vitro, lactoferrin (LF) strongly inhibits human cytomegalovirus (HCMV), which led us to hypothesize that in vivo HCMV might also be inhibited in secretions with high LF concentrations. In breast milk, high viral loads observed as high viral DNA titers tended to coincide with higher LF levels. However, the LF levels did not correlate to virus transmission to preterm infants. The viral load in the transmitting group was highest compared to the nontransmitting group. We conclude that viral load in breast milk is an important factor for transmission of the virus.

* Corresponding author. Mailing address: Groningen University Institute for Drug Exploration (GUIDE), Department of Pharmacy and Drug Delivery, University Center for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands. Phone: 31-50-363-7566. Fax: 31-50-363-3247. E-mail: B.W.A.van.der.Strate{at}farm.rug.nl.

dagger Present address: Yamanouchi Europe B.V., 2353 EW Leiderdorp, The Netherlands.

Clinical and Diagnostic Laboratory Immunology, July 2001, p. 818-821, Vol. 8, No. 4
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.4.818-821.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2001 by the American Society for Microbiology. All rights reserved.