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Clinical and Diagnostic Laboratory Immunology, January 2001, p. 187-189, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.187-189.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

trans-Sialidase Inhibition Assay, a Highly Sensitive and Specific Diagnostic Test for Chagas' Disease

A. S. Buchovsky,1 O. Campetella,2 G. Russomando,3 L. Franco,3 R. Oddone,3 N. Candia,3 A. Luquetti,4 S. M. Gonzalez Cappa,1 and M. S. Leguizamon1,*

Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires,1 and Instituto de Investigaciones Biotecnológicas, Universidad Nacional de San Martin,2 Buenos Aires, Argentina; Instituto de Ciencias de la Salud, Universidad Nacional de Asunción, Paraguay3; and Instituto de Patologia Tropical e Saude Publica, Universidad Federal de Goias, Goiania, Brazil4

Received 9 June 2000/Returned for modification 28 July 2000/Accepted 9 October 2000

For the diagnosis of Chagas' disease, the trans-sialidase inhibition assay was able to resolve the results for samples with borderline results, to detect as positive 60% of samples that were negative by conventional serology, and to discriminate idiopathic from chagasic megaviscera or cardiopathy. No cross-reaction with sera from patients with other diseases was observed.

* Corresponding author. Mailing address: Departamento de Microbiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 13, 1121 Buenos Aires, Argentina. Phone and Fax: 54-11-4963-7078. E-mail: sleguiza{at}fmed.uba.ar.

Clinical and Diagnostic Laboratory Immunology, January 2001, p. 187-189, Vol. 8, No. 1
1071-412X/01/$04.00+0   DOI: 10.1128/CDLI.8.1.187-189.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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Copyright © 2001 by the American Society for Microbiology. All rights reserved.