Prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae Immunoglobulin G and A Antibodies in a Healthy Finnish Population as Analyzed by Quantitative Enzyme Immunoassays

doi:10.1128/CDLI.7.5.734-738.2000

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Clinical and Diagnostic Laboratory Immunology, September 2000, p. 734-738, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae Immunoglobulin G and A Antibodies in a Healthy Finnish Population as Analyzed by Quantitative Enzyme Immunoassays

Tamara Tuuminen,¹^,^* Sirpa Varjo,¹ Heidi Ingman,¹ Theodor Weber,² Jarmo Oksi,³ and Matti Viljanen⁴

Labsystems Research Laboratories, Labsystems OY, 00811 Helsinki,¹ Laakso City Hospital, Lääkärikatu 8, 00250 Helsinki,² and Department of Medical Microbiology, University of Turku,³ and National Public Health Institute, Department in Turku,⁴ 20520 Turku, Finland

Received 31 January 2000/Returned for modification 5 April 2000/Accepted 17 May 2000

Chlamydia pneumoniae and Mycoplasma pneumoniae immunoglobulin G (IgG) and IgA antibody seroprevalence rates and antibody levelsrelated to age and gender were studied. The samples (n = 742)were collected during a nonepidemic period and analyzed by quantitativeenzyme immunoassays (EIAs). Seroprevalence to C. pneumoniae wasfound to increase sharply in young children, and in the 15- to19-year-old group it reached levels as high as 70 and 60% forIgG and IgA, respectively. After adolescence, seroprevalence showeda transient decrease and then continued to increase, althoughless dramatically than in early childhood. In the elderly theseroprevalence of IgG antibodies reached 75 and 100% in womenand men, respectively. The corresponding rates of IgA antibodieswere 73 and 100%. When a randomly selected subgroup of samples(n = 66) was analyzed in parallel by a microimmunofluorescencetest and an EIA for C. pneumoniae IgA antibodies, similar seroprevalencerates were obtained (36 versus 35%). Seroprevalence to M. pneumoniaewas already found to increase very sharply in 2- to 4-year-oldchildren, reaching 16% for IgG and 8% for IgA. Seroprevalenceto M. pneumoniae also continued to increase in adolescence, butin contrast to that to C. pneumoniae, the increase leveled offat about 40 to 50% in adulthood. In subjects aged over 65 years,prevalence did not exceed 60% for IgG or 35% for IgA. The seroprevalencepatterns as well as the medians and variations of levels of C.pneumoniae and M. pneumoniae IgG antibodies were similar to thoseof corresponding IgA antibodies. Compared to IgG antibodies, IgAantibodies do not seem to be of additional value in the diagnosisof infections caused by these pathogens when single serum specimensarestudied.

^* Corresponding author. Mailing address: Labsystems Research Laboratories, Labsystems OY, Sorvaajankatu 15, P.O. Box 208, 00811Helsinki, Finland. Phone: 358-9-32910484. Fax: 358-9-32910531.E-mail: tamara.tuuminen{at}thermobio.com.

Clinical and Diagnostic Laboratory Immunology, September 2000, p. 734-738, Vol. 7, No. 5
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

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