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Clinical and Diagnostic Laboratory Immunology, July 2000, p. 703-705, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Lack of Utility of Specific Immunoglobulin G Antibody Avidity for Serodiagnosis of Reactivated Toxoplasmosis in Immunocompromised Patients

Bénédicte Mechain,1 Yves Jean-François Garin,1 Florence Robert-Gangneux,2 Jean Dupouy-Camet,2 and Francis Derouin1,*

Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, 75475 Paris Cedex 10,1 and Laboratoire de Parasitologie-Mycologie, Hôpital Cochin, 75014 Paris,2 France

Received 30 November 1999/Returned for modification 25 January 2000/Accepted 22 March 2000

The avidities of Toxoplasma-specific immunoglobulin G serum antibodies were measured in immunocompromised patients presenting with cerebral or extracerebral toxoplasmosis and/or serological reactivation. Since avidity remained high and stable in 39 of 40 patients with toxoplasmosis and 27 of 28 patients with serological reactivation, we conclude that this test cannot help diagnose toxoplasmosis in these patients.

* Corresponding author. Mailing address: Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, 1, avenue Claude Vellefaux, 75475 Paris Cedex 10, France. Phone: 33 1 42 49 95 01. Fax: 33 1 42 49 48 03. E-mail: paracord{at}wanadoo.fr.

Clinical and Diagnostic Laboratory Immunology, July 2000, p. 703-705, Vol. 7, No. 4
1071-412X/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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