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Clinical and Diagnostic Laboratory Immunology, January 2000, p. 6-8, Vol. 7, No. 1
1071-412X/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Serum Cytokine Responses during Acute Human Granulocytic Ehrlichiosis

J. S. Dumler,1,* E. R. Trigiani,1,2 J. S. Bakken,3 M. E. Aguero-Rosenfeld,4 and G. P. Wormser5

Department of Pathology, The Johns Hopkins Medical Institutions,1 and Department of Pathology, University of Maryland School of Medicine,2 Baltimore, Maryland; St. Mary's-Duluth Clinic Medical Center, Duluth, Minnesota3; and Department of Pathology4 and Division of Infectious Diseases, Department of Medicine,5 New York Medical College, Valhalla, New York

Received 2 July 1999/Returned for modification 18 August 1999/Accepted 22 September 1999

Human granulocytic ehrlichiosis (HGE) is caused by obligate intracellular bacteria in the Ehrlichia phagocytophila group. The disease ranges from subclinical to fatal. We speculated that cell-mediated immunity would be important for recovery from and potentially in the clinical manifestations of HGE; thus, serum tumor necrosis factor alpha (TNF-alpha ), interleukin 1beta (IL-1beta ), gamma interferon (IFN-gamma ), IL-10, and IL-4 concentrations were studied. IFN-gamma (1,035 ± 235 pg/ml [mean ± standard error of the mean]) and IL-10 (118 ± 46 pg/ml) concentrations were elevated in acute-phase sera versus convalescent sera and normal subjects (P equal 0.013 and P equal 0.018, respectively). TNF-alpha , IL-1beta , and IL-4 levels were not elevated. Cytokine levels in severely and mildly affected patients were not different. HGE leads to induction of IFN-gamma -dominated cell-mediated immunity associated with clinical manifestations, recovery from infection, or both.

* Corresponding author. Mailing address: Division of Medical Microbiology, Department of Pathology, The Johns Hopkins Medical Institutions, Meyer B1-193, 600 N. Wolfe St., Baltimore, MD 21287. Phone: (410) 955-5077. Fax: (410) 614-8087. E-mail: sdumler{at}jhmi.edu.

Clinical and Diagnostic Laboratory Immunology, January 2000, p. 6-8, Vol. 7, No. 1
1071-412X/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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