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Clinical and Diagnostic Laboratory Immunology, September 1999, p. 768-770, Vol. 6, No. 5
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Hepatitis B Virus DNA in Blood Samples Positive for Antibodies to Core Antigen and Negative for Surface Antigen

C. Gutiérrez,1 G. León,2 C. L. Loureiro,1 N. Uzcátegui,1 F. Liprandi,1 and F. H. Pujol1,*

Laboratorio de Biología de Virus, Centro de Microbiología y Biología Cellular, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020-A,1 and Banco Municipal de Sangre, Caracas,2 Venezuela

Received 8 March 1999/Returned for modification 6 May 1999/Accepted 4 June 1999

Anti-hepatitis B core antigen (HBcAg)-positive hepatitis B surface antigen (HBsAg)-negative plasma samples from blood donors were tested by nested PCR. DNA positivity was more significantly associated with high levels of anti-HBcAg than with low levels of anti-HBsAg antibodies. Analysis of a dilution of anti-HBcAg antibodies might result in a more rational exclusion of anti-HBcAg-positive HBsAg-negative samples, reducing the number of donations discarded and enabling more countries to incorporate anti-HBcAg testing.

* Corresponding author. Mailing address: Laboratorio de Biología de Virus, Centro de Microbiología y Biología Celular, Instituto Venezolano de Investigaciones Científicas, Apartado 21827, Caracas 1020-A, Venezuela. Phone and fax: 58.2.504.1623. E-mail: fpujol{at}pasteur.ivic.ve.

Clinical and Diagnostic Laboratory Immunology, September 1999, p. 768-770, Vol. 6, No. 5
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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Copyright © 1999 by the American Society for Microbiology. All rights reserved.