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Clinical and Diagnostic Laboratory Immunology, July 1999, p. 545-549, Vol. 6, No. 4
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Similar Humoral and Cellular Immunological Reactivities to Human Herpesvirus 6 in Patients with Multiple Sclerosis and Controls

Malin Enbom,1,2,* Fu-Zhang Wang,1,2 Sten Fredrikson,3 Claes Martin,3 Helena Dahl,1,2 and Annika Linde1,4

Department of Virology, Swedish Institute for Infectious Disease Control,1 Microbiology and Tumor Biology Center, Karolinska Institute,2 Division of Neurology, Karolinska Institute, Huddinge University Hospital,3 and Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Hospital,4 Stockholm, Sweden

Received 25 January 1999/Returned for modification 18 March 1999/Accepted 28 April 1999

Several studies have suggested an association between human herpesvirus 6 (HHV-6) and multiple sclerosis (MS). We have previously studied intrathecal production of antibody to lymphotropic herpesviruses in MS patients and the presence of human herpesvirus 1 to 7 DNAs in cerebrospinal fluid (CSF). In the present study anti-HHV-6 immunoglobulin M (IgM) in serum and anti-HHV-6 IgG subclasses in serum and CSF were examined and the lymphoproliferative response to HHV-6 was analyzed. The PCR examination was refined by purifying DNA from CSF and retesting the samples for HHV-6 DNA. There were no statistically significant differences between the groups concerning IgM positivity, distribution of IgG subclasses, or lymphoproliferative response to HHV-6. The purification of DNA increased the number of PCR-positive samples from 0 of 71 to 4 of 68. The study does not give additional support to the possibility that HHV-6 is a common cause of MS, but a role for the virus in a subset of patients cannot be excluded.

* Corresponding author. Mailing address: Department of Virology, Swedish Institute for Infectious Disease Control, S-171 82 Solna, Sweden. Phone: 46-8-457 26 26. Fax: 46-8-33 72 72. E-mail: malin_enbom{at}hotmail.com.

Clinical and Diagnostic Laboratory Immunology, July 1999, p. 545-549, Vol. 6, No. 4
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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