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Clinical and Diagnostic Laboratory Immunology, May 1999, p. 410-414, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Immunohematological Reference Ranges for Adult Ethiopians

Aster Tsegaye,* Tsehaynesh Messele, Tesfaye Tilahun, Ermias Hailu, Tefera Sahlu, Ronan Doorly, Arnaud L. Fontanet, and Tobias F. Rinke de Wit

Ethiopian-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia

Received 10 August 1998/Returned for modification 25 September 1998/Accepted 19 January 1999

A cross-sectional survey was carried out with 485 healthy working adult Ethiopians who are participating in a cohort study on the progression of human immunodeficiency virus type 1 (HIV-1) infection to establish hematological reference ranges for adult HIV-negative Ethiopians. In addition, enumeration of absolute numbers and percentages of leukocyte subsets was performed for 142 randomly selected HIV-negative individuals. Immunological results were compared to those of 1,356 healthy HIV-negative Dutch blood donor controls. Immunohematological mean values, medians, and 95th percentile reference ranges were established. Mean values were as follows: leukocyte (WBC) counts, 6.1 × 109/liter (both genders); erythrocyte counts, 5.1 × 1012/liter (males) and 4.5 × 1012/liter (females); hemoglobin, 16.1 (male) and 14.3 (female) g/dl; hematocrit, 48.3% (male) and 42.0% (female); platelets, 205 × 109/liter (both genders); monocytes, 343/µl; granulocytes, 3,057/µl; lymphocytes, 1,857/µl; CD4 T cells, 775/µl; CD8 T cells, 747/µl; CD4/CD8 T-cell ratio, 1.2; T cells, 1,555/µl; B cells, 191/µl; and NK cells, 250/µl. The major conclusions follow. (i) The WBC and platelet values of healthy HIV-negative Ethiopians are lower than the adopted reference values of Ethiopia. (ii) The absolute CD4 T-cell counts of healthy HIV-negative Ethiopians are considerably lower than those of the Dutch controls, while the opposite is true for the absolute CD8 T-cell counts. This results in a significantly reduced CD4/CD8 T-cell ratio for healthy Ethiopians, compared to the ratio for Dutch controls.

* Corresponding author. Mailing address: Ethiopian Health and Nutrition Research Institute (EHNRI), P.O. Box 1242, Addis Ababa, Ethiopia. Phone: 251-1-757751, 251-1-130642, or 251-1-753330. Fax: 251-1-756329. E-mail: enarp{at}telecom.net.et.

Clinical and Diagnostic Laboratory Immunology, May 1999, p. 410-414, Vol. 6, No. 3
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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