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Clinical and Diagnostic Laboratory Immunology, March 1999, p. 273-275, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Murine Model of Renal Abscess Formation

George M. Mussalli,1,dagger Steven R. Brunnert,2 and Emmet Hirsch1,*

Department of Obstetrics and Gynecology1 and The Institute of Comparative Medicine,2 Columbia University College of Physicians and Surgeons, New York, New York

Received 19 August 1998/Returned for modification 29 September 1998/Accepted 30 November 1998

We developed a murine model of kidney abscess by direct renal injection of either Escherichia coli (1 × 106 to 7 × 106 organisms) or sterile medium. Bacterial infection produced renal abscesses, bacteremia, and late-onset leukocytosis in all animals. Controls were unaffected. This model may be useful for the study of various sequelae of kidney infection.

* Corresponding author. Mailing address: Columbia University College of Physicians and Surgeons, Department of Obstetrics and Gynecology, P&S 16-417, 630 W. 168th St., New York, NY 10032. Phone: (212) 305-8693. Fax: (212) 305-3869. E-mail: eh25{at}columbia.edu.

dagger Present address: Albert Einstein College of Medicine, Jack D. Weiler Division, Department of Obstetrics and Gynecology, Bronx, NY 10461.

Clinical and Diagnostic Laboratory Immunology, March 1999, p. 273-275, Vol. 6, No. 2
1071-412X/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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