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Clinical and Diagnostic Laboratory Immunology, September 1998, p. 740-743, Vol. 5, No. 5
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Neutrophil Chemiluminescence during Phagocytosis Is Inhibited by Abnormally Elevated Levels of Acetoacetate: Implications for Diabetic Susceptibility to Infections

Fawzia A. Saeed* and Georgina E. Castle

Department of Biology, St. Mary's College of California, Moraga, California 94575

Received 6 November 1997/Returned for modification 10 March 1998/Accepted 8 July 1998

Human neutrophils by a chemiluminescence assay exhibit diminished phagocytic activity in the presence of abnormally high levels of the serum metabolite acetoacetate. These findings, along with our previous evidence demonstrating myeloperoxidase inhibition by acetoacetate, implicate metabolic ketosis in the inhibition of neutrophil microbicidal activity and thus in increased susceptibility to infections.

* Corresponding author. Mailing address: Department of Biology, P.O. Box 4507, St. Mary's College, Moraga, CA 94575. Phone: (925) 631-4441. Fax: (925) 376-4027. E-mail: fsaeed{at}stmarys-ca.edu.

Clinical and Diagnostic Laboratory Immunology, September 1998, p. 740-743, Vol. 5, No. 5
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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