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Clinical and Diagnostic Laboratory Immunology, September 1998, p. 737-739, Vol. 5, No. 5
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Serotyping Assay for Hepatitis C Virus in Southeast Asia

Sirirurg Songsivilai,* Duangjit Kanistanon, and Tararaj Dharakul

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

Received 16 January 1998/Returned for modification 10 April 1998/Accepted 9 June 1998

A serotyping assay for hepatitis C virus (HCV) was evaluated with samples from Thailand, where the distribution of HCV genotypes was different from that in Western countries where the assay was designed and validated. The sensitivity of the assay was low (58%) for HCV RNA-positive samples compared to that of the genotyping assay (95%, P < 0.01). In addition, only 36% of anti-HCV-positive but HCV RNA-negative samples could be serotyped. The serotypes and genotypes were identical in 96% of the samples that could be typed by both methods. Most of the samples with genotype 6, which was common in Southeast Asia, were nontypeable by this serotyping assay.

* Corresponding author. Mailing address: Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok 10700, Thailand. Phone: 66-2-419-7066. Fax: 66-2-418-1636. E-mail: sissv{at}mahidol.ac.th.

Clinical and Diagnostic Laboratory Immunology, September 1998, p. 737-739, Vol. 5, No. 5
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.