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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 410-411, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effect of Cytokines on Anticryptococcal Activity of Human Microglial Cells

Myriam M. Lipovsky,1,2,dagger Amadu E. Juliana,1,2 Genya Gekker,1 Shuxian Hu,1 Andy I. M. Hoepelman,2 and Phillip K. Peterson1,3,*

Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation,1 and University of Minnesota Medical School,3 Minneapolis, Minnesota, and Division of Infectious Diseases and AIDS, Department of Medicine, University Hospital Utrecht, Utrecht, The Netherlands2

Received 12 December 1997/Returned for modification 28 January 1998/Accepted 25 February 1998

The effect of selected cytokines on the antifungal activity of human microglia was studied with encapsulated and acapsular strains of Cryptococcus neoformans. None of the cytokines tested increased the fungistatic activity of microglia, suggesting that killing of cryptococci within the central nervous system is dependent on other host defense mechanisms.

* Corresponding author. Mailing address: University of Minnesota Medical School, Minneapolis, MN 55415. Phone: (612) 347-2877. Fax: (612) 904-4299. E-mail: peter137{at}maroon.tc.umn.edu.

dagger Present address: Division of Infectious Diseases and AIDS, Department of Medicine, University Hospital Utrecht, Utrecht, The Netherlands.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 410-411, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.