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Clinical and Diagnostic Laboratory Immunology, May 1998, p. 399-400, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Adenosine Deaminase Deficiency and Purine Nucleoside Phosphorylase Deficiency in Common Variable Immunodeficiency

Amy Fleischman,1 Michael S. Hershfield,2 Stephan Toutain,2 Howard M. Lederman,1 Kathleen E. Sullivan,3 Mary Beth Fasano,4 Jeff Greene,3 and Jerry A. Winkelstein1,*

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland1; Department of Medicine, The Duke University School of Medicine, Durham, North Carolina2; and Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania3; and Department of Medicine, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina4

Received 28 October 1997/Returned for modification 10 December 1997/Accepted 19 January 1998

The clinical presentations of adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency are widely variable and include clinical and immunologic findings compatible with common variable immunodeficiency. The screening of 44 patients with common variable immunodeficiency failed to identify any individuals with deficiencies of these enzymes.

* Corresponding author. Mailing address: CMSC 1102, The Johns Hopkins Hospital, Baltimore, MD 21287. Phone: (410) 955-5883. Fax: (410) 955-0229. E-mail: JWINKELS{at}WELCHLINK.WELCH.JHU.EDU.

Clinical and Diagnostic Laboratory Immunology, May 1998, p. 399-400, Vol. 5, No. 3
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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