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Clinical and Diagnostic Laboratory Immunology, March 1998, p. 263-265, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Simple Whole-Blood Test for Detecting Antibodies to Human Immunodeficiency Virus

Willfried Schramm,1,dagger Stephen E. Wade,1 Gustavo Barriga Angulo,2 Patricia Castillo Torres,2 and Anthony Burgess-Cassler1,*

Saliva Diagnostic Systems, Inc., Vancouver, Washington 98682-2444,1 and Clinical Laboratory, Hospital de Infectologia, Centro Medico Nacional la Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico2

Received 8 September 1997/Returned for modification 10 November 1997/Accepted 25 November 1997

We developed an immunochromatographic whole-blood test (WBT) which detects antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) from fingerstick blood. The sensitivity and specificity of the WBT were 99.41% (1,018 confirmed positive patients) and 99.89% (941 uninfected patients), respectively (enzyme immunoassay [EIA] on serum or plasma as a reference). WBT performance was comparable to those of licensed EIAs and Western blotting, using 18 HIV-2 sera, 23 HIV-1 seroconversion panels, and a low-titer performance panel (in lieu of whole blood).

* Corresponding author. Mailing address: Saliva Diagnostic Systems, Inc., 11719 NE 95 St., Vancouver, WA 98682-2444. Phone: (360) 696-4800. Fax: (360) 254-7942. E-mail: saliva1{at}pacifier.com.

dagger Present address: Selfcare, Inc., Waltham, Mass.

Clinical and Diagnostic Laboratory Immunology, March 1998, p. 263-265, Vol. 5, No. 2
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.