CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ehara, M.
Right arrow Articles by Shimodori, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ehara, M.
Right arrow Articles by Shimodori, S.

Clinical and Diagnostic Laboratory Immunology, January 1998, p. 65-69, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Induction of Fimbriated Vibrio cholerae O139

Masahiko Ehara,1,* Mamoru Iwami,1 Yoshio Ichinose,1 Toshiya Hirayama,1 M. John Albert,2 R. Bradley Sack,3 and Shoichi Shimodori4

Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, 1-chome 12-4 Sakamoto, Nagasaki 852,1 and Department of Microbiology, School of Health Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812,4 Japan; Laboratory Sciences Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1000, Bangladesh2; and Division of Geographic Medicine, School of Public Health, Johns Hopkins University, Baltimore, Maryland 212053

Received 10 February 1997/Returned for modification 25 August 1997/Accepted 1 October 1997

Several fimbriated phases of Vibrio cholerae O139 strains were selectively induced and compared immunologically and biochemically with those of V. cholerae O1. Fimbrial antigens were detected on the surfaces of vibrio cells colonizing the epithelial cells of a rabbit small intestine. Convalescent-phase sera from six individuals infected with V. cholerae O139 revealed the development of antibody against the fimbrillin. These findings suggest that the fimbriae of V. cholerae O1 and O139 are expressed in vivo during infection and that consideration must be given to the use of fimbrial antigens as components of vaccines against cholera.

* Corresponding author. Mailing address: Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, 1-chome 12-4, Sakamoto, Nagasaki 852, Japan. Phone: 81(958)497832. Fax: 81(958)497805. E-mail: ehara{at}net.nagasaki-u.ac.jp.

Clinical and Diagnostic Laboratory Immunology, January 1998, p. 65-69, Vol. 5, No. 1
1071-412X/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1998 by the American Society for Microbiology. All rights reserved.