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Clinical and Diagnostic Laboratory Immunology, Jul 1997, 493-495, Vol 4, No. 4
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Presence of a neutralizing domain in isolates of rubella virus in Cordoba, Argentina

P Cordoba, SL Grutadauria, C Cuffini and MT Zapata
Instituto de Virologia J. M. Vanella, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Argentina.

We studied the presence of a neutralizing epitope of rubella virus (RV) in locally circulating strains in Cordoba, Argentina, using binding by the monoclonal antibody (MAb) H3. This epitope is contained in a sequence of the E1 glycoprotein (E1208-239) represented by the synthetic peptide SP15. H3 MAb showed specific binding to SP15 by enzyme-linked immunosorbent assay (ELISA). One wild-type postnatal isolate, four clones derived from this isolate, and one congenital isolate were reactive with H3 by ELISA. These results suggest that the region of RV represented by SP15 is a domain present in locally circulating strains.

This article has been cited by other articles:

• Cordoba, P., Lanoel, A., Grutadauria, S., Zapata, M. (2000). Evaluation of Antibodies against a Rubella Virus Neutralizing Domain for Determination of Immune Status. CVI 7: 964-966 [Abstract] [Full Text]