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Clinical and Diagnostic Laboratory Immunology, 07 1996, 477-479, Vol 3, No. 4
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Prevalence of neutralizing antibody to respiratory syncytial virus in sera from mothers and newborns residing in the Gambia and in The United States

RO Suara, PA Piedra, WP Glezen, RA Adegbola, M Weber, EK Mulholland, BM Greenwood and H Whittle
Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.

The prevalence of maternal respiratory syncytial virus (RSV)- neutralizing antibodies has been documented in developed countries, but there is little information from developing countries. We assessed the prevalence of RSV-neutralizing antibody in sera from Gambian women and their newborns and compared them with their American counterparts during a similar period. The geometric mean titers of maternal antibodies to RSV subgroup A in the two populations were similar, while titers of antibodies to RSV subgroup B in Gambian mothers were significantly higher (8.7 +/- 1.4 versus 7.9 +/- 1.3 [mean +/- standard deviation], P < 0.001). The titers of neutralizing antibody in newborns in both populations correlated with the neutralizing-antibody titers of their mothers. Thus, the status of neutralizing antibody to both major RSV subgroups was comparable among infants and mothers in a developing country, The Gambia, and those in a developed country, the United States.