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Clinical and Diagnostic Laboratory Immunology, Mar 1996, 205-210, Vol 3, No. 2
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

T-cell proliferative response to human papillomavirus type 16 peptides: relationship to cervical intraepithelial neoplasia

M Nakagawa, DP Stites, S Farhat, A Judd, AB Moscicki, AJ Canchola, JF Hilton and JM Palefsky
Department of Laboratory Medicine, School of Medicine, University of California at San Francisco 94143-0134, USA.

The incidence of human papillomavirus (HPV)-related cervical intraepithelial neoplasia (CIN) and cervical cancer is increased with immunodeficiency, but the role of immune response, including cell- mediated immunity, in disease prevention is not well understood. In this study, T-cell proliferative responses to six synthetic peptides with predicted immunogenic determinants from the HPV-16 E4, E6, E7, and L1 open reading frames were analyzed in 22 sexually active women with new-onset CIN and 65 sexually active women without cervical disease, characterized by cytology, colposcopy, and HPV testing. T-cell proliferative responses were demonstrated to all six HPV-16 peptides. Although not statistically significant, rates of reactivity to E6 (24- 45) were higher among sexually active women without disease (26%) than among women with current CIN (7%), as was the overall number of peptides stimulating a response. Women with CIN may not respond to selected HPV antigens as well as women without disease do.

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