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Clinical and Diagnostic Laboratory Immunology, Jan 1996, 93-97, Vol 3, No. 1
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Long-term human serum antibody responses after immunization with whole- cell pertussis vaccine in France

E Grimprel, P Begue, I Anjak, E Njamkepo, P Francois and N Guiso
Hopital d'enfants Armand-Trousseau, Paris, France.

Three hundred sixty children were tested for pertussis serology 0.5 to 1.58 months after complete whole-cell pertussis vaccination. An immunoblot assay was used to detect serum antibodies to pertussis toxin, filamentous hemagglutinin, adenylate cyclase-hemolysin, and pertactin, and agglutination was used for detection of anti- agglutinogen antibodies. Antibodies against pertussis toxin, pertactin, and agglutinogens decreased rapidly after vaccination but increased secondarily, suggesting exposure to infected persons. In contrast, anti- filamentous hemagglutinin antibodies persisted and anti-adenylate cyclase-hemolysin antibodies increased continuously, suggesting either cross-reaction with non-Bordetella antigens or exposure to Bordetella isolates expressing these two antigens, including Bordetella pertussis. These data suggest that unrecognized pertussis is common in France despite massive and sustained immunization in infants and that vaccinated children become susceptible to infection more than 6 years after their last vaccination.

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• Weber, C., Boursaux-Eude, C., Coralie, G., Caro, V., Guiso, N. (2001). Polymorphism of Bordetella pertussis Isolates Circulating for the Last 10 Years in France, Where a Single Effective Whole-Cell Vaccine Has Been Used for More than 30 Years. J. Clin. Microbiol. 39: 4396-4403 [Abstract] [Full Text]  
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