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Clinical and Diagnostic Laboratory Immunology, Jan 1996, 132-134, Vol 3, No. 1
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Detection of anti-neutrophil cytoplasmic antibodies after acute Plasmodium falciparum malaria

C Wenisch, H Wenisch, HC Bankl, M Exner, W Graninger, S Looareesuwan and H Rumpold
Department of Infectious Diseases, Internal Medicine I, University Hospital of Vienna, Austria.

Four of 30 patients with Plasmodium falciparum infection in Bangkok, Thailand, were positive for anti-neutrophil cytoplasmic antibodies by indirect immunofluorescence 1 month after antimalarial therapy. No myeloperoxidase, proteinase 3, lactoferrin, or elastase reactivity was found. Since no evidence of vasculitis was seen in these patients, anti- neutrophil cytoplasmic antibody production in malaria-infected susceptible patients probably represents a secondary response, indicating neutrophil activation.

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