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Clinical and Diagnostic Laboratory Immunology, Nov 1995, 760-762, Vol 2, No. 6
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

A family cluster of an immune escape variant of hepatitis B virus infecting a mother and her two fully immunized children

MS Ho, CF Lu, J Kuo, YC Mau and WH Chao
Division of Epidemiology & Public Health, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

A hepatitis B virus (HBV) immune escape variant which results from a substitution of glycine by arginine at position 145 (arginine-145) in the immunodominant neutralization epitope of the S protein was found to infect one child in a seroepidemiologic survey of 1,812 vaccinated children. The child's mother and a younger brother were also infected by the same HBV variant, despite a greater than accepted level of protective antibody (anti-HBV surface antigen) in both the index child (30 mIU/ml) and the brother (> 20,000 mIU/ml). Our findings suggest the perinatal or horizontal transmission of the arginine-145 HBV variant from mother to child, but the ability of this variant to propagate among the vaccinated children remains unknown.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
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Copyright © 1995 by the American Society for Microbiology. All rights reserved.