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Clinical and Diagnostic Laboratory Immunology, Jul 1995, 492-495, Vol 2, No. 4
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Cytokines in the stools of children with complicated shigellosis

T Azim, RC Halder, MS Sarker, S Ahmed, J Hamadani, A Chowdhury, F Qadri, MA Salam, RB Sack and MJ Albert
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.

The pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF- alpha) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-alpha in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool IL-6 and TNF-alpha concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and < 0.001, respectively) or in uninfected children (P < 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-alpha in stool.


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Copyright © 1995 by the American Society for Microbiology. All rights reserved.