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Clinical and Diagnostic Laboratory Immunology, May 1995, 381-384, Vol 2, No. 3
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Impaired expression of interleukin 2 receptor and CD45RO antigen on lymphocytes from children with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus

K Mizutani, M Ito, T Nakano, H Kamiya and M Sakurai
Department of Pediatrics, Mie University School of Medicine, Japan.

The expression of CD25 and CD45RO in lymphocytes from patients with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus antigens was analyzed by flow cytometry. It is suggested that the defects in the immune response to cytomegalovirus and varicella-zoster virus in patients with acute lymphoblastic leukemia on chemotherapy are in the expression of CD25 and in the switching of CD45RA cells to CD45RO cells.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1995 by the American Society for Microbiology. All rights reserved.