This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zucker-Franklin, D. Articles by Grusky, G. Search for Related Content PubMed PubMed Citation Articles by Zucker-Franklin, D. Articles by Grusky, G.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, May 1995, 343-348, Vol 2, No. 3
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Interaction of human immunodeficiency virus type 1, human T-cell leukemia/lymphoma virus type I (HTLV-I), and HTLV-II with in vitro- generated dendritic cells

D Zucker-Franklin, M Fraig and G Grusky
Department of Medicine, New York University Medical Center, New York 10016, USA.

Although it is known that impairment of dendritic cells (DC) plays a role in the pathogenesis and immunosuppression of retrovirus-associated diseases, it is not clear whether, or to what extent, these antigen- presenting cells themselves become infected. The realization that the cells can be generated in vitro in larger numbers than can be isolated from circulating blood or bone marrow raised the possibility that they could be used for therapeutic purposes. Therefore, we investigated whether DC generated in vitro from CD34 precursors are susceptible to infection when cocultured with human immunodeficiency virus type 1- or human T-cell leukemia/lymphoma virus-infected cell lines. While there appears to be a remarkable affinity of the viruses for the plasma membranes of the DC, interiorization or budding was not observed in 30 experiments carried out under a variety of conditions.

This article has been cited by other articles:

• Hladik, F., Liu, H., Speelmon, E., Livingston-Rosanoff, D., Wilson, S., Sakchalathorn, P., Hwangbo, Y., Greene, B., Zhu, T., McElrath, M. J. (2005). Combined Effect of CCR5-{Delta}32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission. J. Virol. 79: 11677-11684 [Abstract] [Full Text]  
• Makino, M., Shimokubo, S., Wakamatsu, S.-I., Izumo, S., Baba, M. (1999). The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis. J. Virol. 73: 4575-4581 [Abstract] [Full Text]