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Clinical and Diagnostic Laboratory Immunology, Mar 1995, 246-248, Vol 2, No. 2
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Methods for detection of an intestinal secretory immunoglobulin A response to Candida spp. and their preliminary application in human immunodeficiency virus-infected patients with chronic diarrhea

EG Scerpella, SS Gould, JJ Mathewson and HL DuPont
Center for Infectious Diseases, University of Texas Medical School, Houston.

Six of 11 human immunodeficiency virus (HIV)-infected patients with chronic diarrhea, shedding only Candida spp. in their stools, elicited a Candida-specific secretory immunoglobulin A response. Similar responses were identified in only 1 of 10 HIV-positive patients with chronic diarrhea but without Candida spp. and in none of 10 HIV- negative subjects without diarrhea. Candida spp. may play a role in the etiology of chronic diarrhea associated with HIV infection.