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Clinical and Diagnostic Laboratory Immunology, 03 1995, 241-245, Vol 2, No. 2
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Are soluble factors relevant for polymorphonuclear leukocyte dysregulation in septicemia?

C Wenisch and W Graninger
Department of Infectious Diseases, University Hospital of Vienna, Austria.

Polymorphonuclear leukocytes (PMNs) of twelve patients with gram- negative septicemia exhibited a decreased capacity to phagocytize Escherichia coli and generate reactive oxygen products which normalized within 7 days of treatment. Ex vivo exchange of plasma from age-, sex-, and blood-group-identical normal controls resulted in an increase of both phagocytic capacity and reactive oxygen intermediate generation in PMNs of septicemic patients and transiently reduced phagocytosis and reactive oxygen intermediate production in PMNs of normal controls. These results suggest that extrinsic factors are crucial for PMN function.

This article has been cited by other articles:

• Wenisch, C., Fladerer, P., Patruta, S., Krause, R., Horl, W. (2001). Assessment of Neutrophil Function in Patients with Septic Shock: Comparison of Methods. CVI 8: 178-180 [Abstract] [Full Text]